D-serine in Schizophrenia (DSRSZ)

Herzog Hospital

Status: Unknown

Conditions: Schizophrenia

Treatments: Dietary Supplement: D-serine

Study type: Observational

Funder types: Other

Identifiers

NCT03702933

HerzogHospital

Details and patient eligibility

About

This study will assess the effects of D-serine adjuvant treatment to the ongoing pharmacological treatment of schizophrenia patients that are resistant to treatments.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• DSM-5 Schizophrenia criteria, able and willing to give informed consent, and comply to study procedure, adequate contraception, post-menopausal or abstinent, PANSS Total Score equal or greater than 70, score of 4 or greater on two psychotic items

Exclusion criteria

• clinically significant, uncontrollable or unstable medical condition, mental retardation or severe organic brain syndrome, significant risk of suicide or violent behavior

Trial design

40 participants in 3 patient groups

Placebo

Description:

starch

Treatment:

Dietary Supplement: D-serine

High Dose

Description:

3.5 g/d D-serine adjuvant treatment

Treatment:

Dietary Supplement: D-serine

Low Dose

Description:

2.1 g/d D-serine adjuvant treatment

Treatment:

Dietary Supplement: D-serine