D1 vs D2 Lymphadenectomy in Gastric Cancer

Fundación para la Investigación del Hospital Clínico de Valencia

Status: Completed

Conditions: Gastric Cancer

Treatments: Procedure: Lymphadenectomy type

Study type: Observational

Funder types: Other

Identifiers

NCT05253430

2021/115

Details and patient eligibility

About

This study is a retrospective study with a propensity score-matched analysis in order to balance differences between patients with D1 and D2 lymphadenectomy for gastric cancer.The main aim is to analyse differences in the postoperative and oncological outcomes of patients with gastric cancer (GC) who underwent D1 and D2 gastrectomy.

Full description

In this propensity score-matched analysis of 128 patients, D2 lymphadenectomy improved long-term outcomes compared with D1 in patients with curative intent surgery for gastric cancer except for the group of patients older than 75 years and with early tumors.

Enrollment: 357 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with GC stage I-III who underwent a curative gastrectomy +/- perioperative chemotherapy

Exclusion criteria

• patients with adenocarcinoma Siewert type I/II, palliative surgery, R1/R2 resections and pathological stage (pStage) IV.

Trial design

357 participants in 2 patient groups

D1 lymph node dissection (LND)

Description:

Patients with gastric cancer that underwent curative surgery with gastrectomy and D1 lymph node dissection

D2 lymph node dissection (LND)

Description:

Patients with gastric cancer that underwent curative surgery with gastrectomy and D2 lymph node dissection

Treatment:

Procedure: Lymphadenectomy type