Da Qing Offspring Study

China-Japan Friendship Hospital

Status: Invitation-only

Conditions: Prevention; Inter- and Transgenerational Inheritance; Impaired Glucose Tolerance (Prediabetes); Offspring, Adult; Diabetes Mellitus; Cancer; Cardiovascular Diseases (CVD); Comorbidity

Treatments: Behavioral: Lifestyle interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06958640

2022-NHLHCRF-YS-01

Details and patient eligibility

About

This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.

Enrollment: 5,000 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Spouses of the original Daqing diabetes Prevention Research Population (IGT), offspring 1 to 3 generations, and offspring spouses were included in the study, without special restrictions on subjects' gender, age, basic disease status, etc。
• Conduct a death agent investigation for some deceased members.

Exclusion criteria

▪People who are unwilling to participate in this study

Trial design

5,000 participants in 2 patient groups

Lifestyle intervention subjects and offspring group

Description:

The subjects who received lifestyle intervention in the original Daqing Diabetes Prevention Study, their spouses, children 1 to 3, and spouses of their offspring were included in the study.

Treatment:

Behavioral: Lifestyle interventions

Control group subjects and offspring

Description:

The subjects who did not received lifestyle intervention in the original Daqing Diabetes Prevention Study, their spouses, children 1 to 3, and spouses of their offspring were included in the study.