Dachaihu Decoction Compound and Rhubarb Single Medicine in the Treatment of Acute Pancreatitis

Fifth Affiliated Hospital, Sun Yat-Sen University

Status: Not yet enrolling

Conditions: Acute Pancreatitis

Treatments: Combination Product: Regular therapies; Drug: Rhubarb single medicine; Combination Product: Dachaihu decoction compound

Study type: Interventional

Funder types: Other

Identifiers

NCT04990336

ZDWY.XHNK.003

Details and patient eligibility

About

A large number of clinical studies have shown that oral administration, external application or enema of Chinese medicine can promote the recovery of gastrointestinal function and the absorption of pancreatic inflammation. The aims of the study is to explore the application of Dachaihu Decoction Compound (DDC)and Rhubarb Single Medicine (RSM) in the Treatment of Acute Pancreatitis.

Enrollment: 306 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 65 years old
• Meet the diagnostic criteria of western medicine for acute pancreatitis, within 48 hours of onset
• Consent of the subjects, who sign the informed consent form

Exclusion criteria

• Women who are pregnant or breastfeeding
• Acute abdomen such as organic intestinal obstruction, gastrointestinal perforation, purulent cholangitis, etc.
• Patients with a history of severe heart, liver, kidney and other important organ diseases
• Patients with mental illness and malignant tumors
• People who have allergies, or are allergic to a certain drug ingredient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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306 participants in 3 patient groups

DDC(Dachaihu decoction compound) Group

Experimental group

Description:

Treated with Dachaihu decoction compound and regular therapies

Treatment:

Combination Product: Regular therapies

Combination Product: Dachaihu decoction compound

RSM(rhubarb single medicine) Group

Active Comparator group

Description:

Treated with rhubarb single medicine and regular therapies

Treatment:

Combination Product: Regular therapies

Drug: Rhubarb single medicine

N Group

Other group

Description:

Treated with regular therapies and without traditional Chinese medicine

Treatment:

Combination Product: Regular therapies