Daily Magnesium-supplement for Severe Asthmatics

University of Aarhus

Status: Completed

Conditions: Asthma

Treatments: Other: Placebo; Dietary Supplement: Mablet (Magnesium-supplement)

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01113151

9727c

Details and patient eligibility

About

The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that a daily magnesium supplement will benefit patients with asthma and chronic obstructive pulmonary disease.

The aim of this part of the project is to reveal possible beneficial effects of daily magnesium supplement for severe asthmatics, refractory to conventional treatment.

Enrollment: 5 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe asthmatics, refractory to conventional treatment, including systemic steroid treatment; symptoms must be annual.

Exclusion criteria

• Se-Mg > 2,00 mmol/L,
• smoking cessation less than 1 year prior to study start,
• major changes in eating habits within three months prior to study start and during the study period of approximately one year,
• various conditions (e.g. gastrointestinal disease, kidney disease, pregnancy/lactation) that may affect the study results.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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5 participants in 3 patient groups, including a placebo group

Washout

No Intervention group

Mablet

Active Comparator group

Treatment:

Dietary Supplement: Mablet (Magnesium-supplement)

Placebo

Placebo Comparator group

Treatment:

Other: Placebo