Daily Magnesium-treatment of Patients With Chronic Obstructive Pulmonary Disease

University of Aarhus

Status: Completed

Conditions: COPD

Treatments: Dietary Supplement: Magnesium supplement (magnesium hydroxide/ -oxide); Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01118936

9727e

Details and patient eligibility

About

The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that a daily magnesium supplement will benefit patients with asthma and chronic obstructive pulmonary disease.

The aim of this part of the project is to study the effect of a daily magnesium supplement for COPD-patients

Enrollment: 11 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD-patients, grade moderate-severe (FEV1 30-80 % of expected. FEV1/FVC < 0,7).

Exclusion criteria

• Se-Mg > 2,00 mmol/L, smoking cessation less than 1 year prior to study start, submission to hospital within the last two years, submission to hospital with exacerbation during the study period, major changes in eating habits within three months prior to study start and during the study period of approx.one year various conditions (e.g. gastrointestinal disease, kidney disease, pregnancy/lactation) that may affect the study results.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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11 participants in 3 patient groups, including a placebo group

Washout

No Intervention group

Mablet

Active Comparator group

Treatment:

Dietary Supplement: Magnesium supplement (magnesium hydroxide/ -oxide)

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo