Danish Angle Closure Prevention Trial (DAP)

University of Aarhus

Status: Enrolling

Conditions: Primary Angle Glaucoma Closure Suspect

Treatments: Procedure: Iridotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT06077253

DAP

Details and patient eligibility

About

To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.

Full description

Prospective, randomised paired-eye design clinical trial comparing peripheral laser iridotomy in one eye with observation in the other over 5-years follow-up.

Enrollment: 242 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary angle closure suspect: ≥180 degrees (cumulative) irido-trabecular contact on darkroom gonioscopy, IOP<21mmHg, no peripheral anterior synechiae, no glaucomatous optic neuropathy
• Best-corrected visual acuity (BCVA) >0.8 on both eyes
• Caucasian

Exclusion criteria

• Pseudophakia
• Previous iridotomy
• Clinically significant cataract with indication for surgery,
• Gaucoma
• Uveitis
• Unstable retinal conditions
• Ocular malignancies
• PEX
• PDS
• Systemic or ocular corticosteroid treatment

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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242 participants in 1 patient group

Arm 1

Other group

Description:

One eye iridotomy, contralateral eye no intervention

Treatment:

Procedure: Iridotomy