DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction (DANAMI-3)

Rigshospitalet

Status: Active, not recruiting

Conditions: ST Segment Elevation Myocardial Infarction

Treatments: Other: Deferred stenting in primary PCI.; Other: Ischemic postconditioning.; Other: Conventional primary PCI

Study type: Interventional

Funder types: Other

Identifiers

NCT01435408

DANAMI-3

Details and patient eligibility

About

This study focuses on Cardioprotective strategies.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years.
• Acute onset of chest pain of < 12 hours' duration.
• ST-segment elevation ≥ 0.1 mV in ≥ 2 contiguous leads, signs of a true posterior infarction or documented newly developed left bundle branch block.

Culprit lesion in a major native vessel.

Exclusion criteria

• Pregnancy.
• Known intolerance of ASA, clopidogrel, heparin or contrast.
• Inability to understand information or to provide informed consent.
• Haemorrhagic diathesis or known coagulopathy.
• Stent thrombosis.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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2,000 participants in 3 patient groups

Conventional treatment.

Active Comparator group

Description:

Conventional primary PCI in STEMI.

Treatment:

Other: Conventional primary PCI

IPost

Experimental group

Description:

Ischemic postconditioning in STEMI.

Treatment:

Other: Ischemic postconditioning.

Deferred primary PCI.

Experimental group

Description:

Deferred strategy in STEMI.

Treatment:

Other: Deferred stenting in primary PCI.