DAPHNE Scale Validation in Frontotemporal Lobar Degeneration

Nantes University Hospital (NUH)

Status: Completed

Conditions: Frontotemporal Lobar Degeneration

Treatments: Other: Psycho-behavioural assessment

Study type: Observational

Funder types: Other

Identifiers

NCT02889601

RC12_0463

Details and patient eligibility

About

Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD). DAPHNE scientific staff have therefore developed a quantification and follow-up scale specifically dedicated to patients with FTD in current clinical practice. This scale is called DAPHNE to Disinhibition, Apathy, Perseveration, Hyper orality, Negligence and loss of Empathy.

Full description

Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD). DAPHNE scientific staff have therefore developed a quantification and follow-up scale specifically dedicated to patients with FTD in current clinical practice. This scale is called DAPHNE to Disinhibition, Apathy, Perseveration, Hyperorality, Negligence and loss of Empathy. This study aims to validate this scale. This validation will include methodological steps required to develop a new clinical tool, by studying internal consistency, loyalty, and concurrent validity in comparison with validated existing tools. Complementarily, sensitivity and specificity will be assessed via a control population including patients with Alzheimer's disease, , progressive supranuclear palsy and bipolar disorder with cognitive disorders.

Enrollment: 89 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Group 1:

1. Patients with FTD according Neary (1998) and Raskowsky (2011) diagnostic criteria.
2. Mini-Mental State Examination ≥ 18
3. Consent

Group 2 Control:

1. Patients with Alzheimer's disease (MacKahn, 2011), patients with supranuclear palsy (Litvan, 1996) and patients with bipolar disorder with cognitive disorders.

   criteria.

2. Mini-Mental State Examination ≥ 18

3. Consent

Exclusion criteria

• Minor patient

Trial design

89 participants in 2 patient groups

Fronto-temporal lobar degeneration

Description:

DAPHNE score building and internal validation through Fronto-temporal lobar degeneration patients.

Treatment:

Other: Psycho-behavioural assessment

Control

Description:

External validation of DAPHNE score among patients with Alzheimer's disease, progressive supranuclear palsy and bipolar disorder with cognitive disorders.

Treatment:

Other: Psycho-behavioural assessment