Data Collection Study From Donors and Recipients to Optimize Donor-recipient Matching in Liver Transplantation (OPTIMATCH-LT)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Liver Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT03371264

P13639

Details and patient eligibility

About

A major limitation of liver transplantation is organ shortage. To avoid exposing patients to death on the waiting list, organs are used that would have been discarded few years ago. Graft allocation is regulated by the "agence de biomedecine" which establishes a national score. Each liver graft is proposed to the patient presenting the higher score. Acceptance or rejection of the graft only depends on the decision of each centre. We propose to submit a more efficient allocation model (enabling each proposed liver graft to be transplanted in the candidate whose transplantation will afford the greatest survival benefit after registration), by collecting and analysing variables from donors and candidates/recipients.

Enrollment: 9,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver transplant candidates : All adult LT candidates listed on the French wait list between 2009 and 2014 and followed prospectively by the mean yearly follow-up under the control of ABM.
• Donors : all adults donors registered over the same 2009-2014 period, including donors whose livers were procured and transplanted, whose liver were procured and discarded, and donors in whom liver was not harvested.

Exclusion criteria

• Pediatric recipients
• Pediatric donors

Trial design

9,000 participants in 2 patient groups

Cohort R1 and Cohort T1

Description:

Cohort R1 (patients on the waiting list between 2009 and 2013) and Cohort T1 (transplanted patients between 2009 and 2013)

Cohort R2 and Cohort T2

Description:

Cohort R2 (patients on the waiting list in 2014) and Cohort T2 (transplanted patients in 2014)