Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis

V.K.V. American Hospital, Istanbul

Status: Completed

Conditions: Fertilization in Vitro; Preservation of Supernumerary Embryos

Treatments: Procedure: Vitrification; Procedure: Slow freezing

Study type: Interventional

Funder types: Other

Identifiers

NCT00608010

AH-ART-06/13

Details and patient eligibility

About

Embryo preservation through freezing plays a significant role in human assisted reproduction. It provides an opportunity for patients to have more than one attempt following an ovarian stimulation cycle, thereby decreasing the exposure of patients to exogenous gonadotrophins and improving cumulative pregnancy rates. The purpose of this study is to compare effectiveness of two different freezing methods.

Enrollment: 186 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICSI with own gametes
• Couples who did not wish to cryopreserve their excess embryos for possible transfer in a future cyle
• Donating excess embryos for research purposes

Exclusion criteria

• Embryos derived from surgically retrieved spermatozoa
• Blastocysts
• Embryos of low quality (Grade 3 or 4 according to Hardarson)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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186 participants in 2 patient groups

1

Experimental group

Description:

Vitrification

Treatment:

Procedure: Vitrification

2

Active Comparator group

Description:

Slow freezing

Treatment:

Procedure: Slow freezing