Dead Space Evaluation in Pulmonary Hypertension

Centro Cardiologico Monzino

Status: Completed

Conditions: Pulmonary Hypertension

Treatments: Other: cardiopulmonary exercise test,hypoxia and hypercapnia test

Study type: Interventional

Funder types: Other

Identifiers

NCT02892981

ccm257

Details and patient eligibility

About

Aim of the study is to evaluate the role of chemoreceptor activity and ventilation perfusion mismatch on the genesis of exercise induced hyperventilation in Pulmonary hypertension patients. So the investigators tested the chemoreceptor response at rest, both with hypoxic and hypercapnic stimuli, and the ventilatory response during exercise analyzing its two components, alveolar and dead space ventilation.

Enrollment: 18 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 and ≤ 80 years
• ability to understand the research protocol and willing to sign the study informed consent
• diagnosis of pulmonary arterial hypertension belonging to Class I and IV
• stable haemodynamic status and optimized medical treatment since at least 2 months
• ability to perform maximal cardiopulmonary exercise test and pulmonary diffusing capacity for carbon monoxide evaluation

Exclusion criteria

• relevant comorbidities
• usual contraindications for cardiopulmonary exercise test
• pulmonary hypertension associated to left heart and pulmonary disease, congenital heart diseases with evident cardiac shunts.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Pulmonary hypertension patients

Other group

Description:

All Pulmonary hypertension patients enrolled in the study underwent a cardiopulmonary exercise test and hypoxia and hypercapnia tests

Treatment:

Other: cardiopulmonary exercise test,hypoxia and hypercapnia test