Dealcoholized Muscadine Wine and Skin Health in Women

University of Florida

Status: Completed

Conditions: Skin Health

Treatments: Other: Control Beverage; Other: Dealcoholized Muscadine Wine

Study type: Interventional

Funder types: Other

Identifiers

NCT04614753

IRB202000789

Details and patient eligibility

About

The objective of this clinical trial is to determine the activity of dealcoholized muscadine wine to alleviate oxidative stress, inflammation, skin photoaging, and alter gut microbiome in women 40-67 years of age. The investigators hypothesize that dealcoholized muscadine wine daily for 42 days will significantly alleviate oxidative stress, inflammation, skin photoaging, and alter the gut microbiome in women compared to drinking sugar water.

Full description

Aging of the skin is characterized by wrinkling, sagging, and laxity. About 80% of facial skin aging is classified as extrinsic, or photoaging because it results from exposure to UV light of the sun that causes oxidative stress The remaining 20% of facial aging is the intrinsic type which is partially caused by the accumulation of proteins that are modified by reactive carbonyls in a reaction known as protein glycation. Aging also shifts the composition of the gut microbiome in at least 35 genera towards an unhealthy state of dysbiosis.

Previous studies showed that muscadine polyphenols inhibited protein glycation under a simulated physiological condition. Additional experiments using cell culture and mice showed that dealcoholized muscadine wine alleviated inflammation and protected against dysbiosis in the gut. The objective of this research is to confirm the health benefits of muscadine wine polyphenols in a clinical trial. The investigators hypothesize that dealcoholized muscadine wine consumption in women 40-65 years old will alleviate skin photoaging and skin conditions by decreasing oxidative stress and inflammation. It is also expected to improve the composition of the gut microbiome.

Enrollment: 20 patients

Sex: Female

Ages: 40 to 67 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy,
• BMI 20.0-29.9
• Fitzpatrick skin type 2 and 3.

Exclusion criteria

• pregnancy
• breast-feeding
• smoking
• alcohol use
• history of skin cancer
• intake of medication that might influence the outcome of the study
• sunbathing or the use of tanning bed
• intake of vitamin/mineral supplements

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups

Dealcoholized Muscadine Wine

Active Comparator group

Description:

Participants in this arm will receive 300ml of dealcoholized muscadine wine daily for six weeks. After a 7- day run-in period, participants will receive dealcoholized muscadine wine daily for six weeks

Treatment:

Other: Dealcoholized Muscadine Wine

Other: Control Beverage

Control Beverage

Active Comparator group

Description:

Participants in this arm will receive 300 ml of sugar water and acid content for six weeks. After a 7-day run in period, participants will receive sugar water for six weeks.

Treatment:

Other: Dealcoholized Muscadine Wine

Other: Control Beverage