Debate on Progesterone Elevation on the Day of Triggering (PE)

Istituto Clinico Humanitas

Status: Completed

Conditions: Female Infertility; Progesterone; Embryo Transfer; ART

Treatments: Other: embryo transfer

Study type: Observational

Funder types: Other

Identifiers

NCT04253470

2020xxxx

Details and patient eligibility

About

The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology.

This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016.

All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.

Enrollment: 8,000 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All fresh embryo transfers both at cleavage stage (Day 2 and Day3) and blastocyst stage (Day 5)
• Thawed embryo transfer deriving from supernumerary embryos cycles, by P increase, by OHSS, by other reasons (i.e inadequate endometrium, medical complications, etc)

Exclusion criteria

• thawed embryo transfers deriving from PGTA.

Trial design

8,000 participants in 2 patient groups

cleavage stage embryo

Description:

embryo which is on day 2 or 3

Treatment:

Other: embryo transfer

blastocyst embryo

Description:

embryo which is on day 5

Treatment:

Other: embryo transfer