Decision-making After Sleep Restriction (DM-SR)

Christian Baumann

Status

Completed

Conditions

Sleep Restriction

Treatments

Other: Acoustic stimulation

Behavioral: Sleep restriction

Study type

Interventional

Funder types

Other

Identifiers

NCT03692962

DM-SR

Details and patient eligibility

About

The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk seeking during chronic sleep restriction. To this end, a controlled, counter-balanced study, consisting of two weeks of sleep restriction will be performed. During one of the sleep restriction weeks, sleep intensity in the PFC will be non-invasively enhanced by acoustic stimulation of slow waves during sleep.

Enrollment

28 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age between 18-21 years or 26-30 years,
Right-handedness,
Good general health,
Good understanding of German language (as all information is provided in German)
Signed Informed Consent after being informed.

Exclusion criteria

Contraindications on ethical grounds,
Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc),
Known or suspected non-compliance, drug or alcohol abuse (> 5dl wine/ >1l beer daily),
Regular medication intake,
Enrolment into a clinical trial within last 4 weeks,
Diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases),
Sleep disorders (e.g. Insomnia, sleep apnoea, restless leg syndrome, narcolepsy, etc.),
Sleep complaints in general or excessive daytime sleepiness (Pittsburgh Sleep Quality Index > 5; Epworth Sleepiness Scale ≥ 11),
Irregular sleep-wake rhythm (e.g. shift working),
Long (> 10 hours per night) or short sleepers (< 7 hours per night),
Sleep efficiency < 80% in screening night,
Travelling with time lag less than 1 month ago (or planning to do so within 1 month prior to or during the study),
> 5 drinks or food items containing caffeine per day,
> 5 cigarettes per day,
Body Mass Index < 19 or > 30 kg/m2,
Skin allergy or very sensitive skin
Student of one of the following subjects: Mathematics, Physics, Computer Science, Economics, or Psychology (since students of these subjects have profound knowledge of probability calculations, which could interfere with our measurements in decision-making).
Red-Green Colour-Blindness (as the Risk Task requires the distinction between red and green),
History of claustrophobia,
Known hearing disorder (as acoustic stimuli will be applied during sleep),
Magnetic Resonance (MR) contraindication (such as pacemaker, implanted pumps, shrapnel, etc.; full MR Screening form will be filled out).