Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

Mass General Brigham

Status

Completed

Conditions

Binge-Eating Disorder

Treatments

Behavioral: Speaking Activity

Behavioral: Talking Activity

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04125589

K23DK120517 (U.S. NIH Grant/Contract)

2018P001468

Details and patient eligibility

About

The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.

Enrollment

77 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Inclusion Criteria for All Participants:

Normal or corrected to normal vision and hearing
Verbal and written fluency in English
Right-handed
Body mass index of 20-35 kg/m^2

Additional Inclusion Criteria for Participants with Binge-Eating Disorder:

• DSM-5 binge-eating disorder

Exclusion criteria

Exclusion Criteria for All Participants:

Impaired cognition or other neurological/cognitive problems
Contraindications to MRI (e.g., certain metal implants, claustrophobia)
Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding
Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions
Recent low weight
Certain medications (e.g., insulin)
Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence
Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods
Current/recent suicidality
Current/recent changes in treatment for mental illness
Study-relevant research experience

Additional Exclusion Criteria for Comparison Participants:

Personal history of eating disorders or recurrent binge eating
Personal history of any other mental illness, including serious substance use problems
First-degree relative with current or past eating or psychotic disorder
Significant recent change in weight

Additional Exclusion Criteria for Participants with Binge-Eating Disorder:

Severe mental illness (e.g., psychotic disorder, severe agoraphobia)
Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety
Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder