Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study

The Chinese University of Hong Kong

Status: Enrolling

Conditions: Dementia, Mild; Cognitive Deterioration; Age-related Cognitive Decline

Treatments: Diagnostic Test: Ageing

Study type: Observational

Funder types: Other

Identifiers

NCT05728801

2019.078

Details and patient eligibility

About

This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive disorder (NCD) patients will be re-invited from our previous cohort (2013-2014) (N=488).

Full description

Objectives: This study aims to investigate the cognitive changes in older adults with different cognitive statuses.

Enrollment: 400 estimated patients

Sex: All

Ages: 60 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest;
• Normal aging: the cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0;
• NCD patients are defined as: evidence of modest decline in one or more cognitive domains, which is set as ≥ 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.

Exclusion criteria

• History of bipolar disorders or psychosis;
• History of major neurological deficits including stroke, transient ischemic attack or traumatic brain injury;
• Comorbidities with depressive symptoms.

Trial design

400 participants in 3 patient groups

Superagers

Description:

SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest.

Treatment:

Diagnostic Test: Ageing

Normal ageing elderly

Description:

The cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0

Treatment:

Diagnostic Test: Ageing

Neurocognitive disorders patients

Description:

NCD patients are defined as: evidence of modest decline in one or more cognitive domains, which is set as ≥ 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.

Treatment:

Diagnostic Test: Ageing