Decoding the Extracellular Vesicles-driven Communication in the Microenvironment of Hairy Cell Leukemia to Improve Patient Care Management

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Enrolling

Conditions: Hairy Cell Leukemia (HCL)

Study type: Observational

Funder types: Other

Identifiers

NCT06774677

HCL-EV

PNRR-TR1-2023-12377450 (Other Grant/Funding Number)

Details and patient eligibility

About

This is a national multi-centre, experimental, cross-sectional, non-profit study.

Full description

Extracellular vesicles are small particles circulating in plasma and documented as key players of intercellular crosstalk thanks to their cargo of proteins, lipids, and nucleic acids. The driving hypothesis of this study is that in Hairy Cell Leukemia-derived extracellular vesicles contribute to the maintenance of the tumor clone through regulation of selected key cells of the tumor microenvironment including immune cells and stromal cells, likely favoring immune evasion and marrow fibrosis. As a consequence, these circulating particles may be instrumental at identifying a biology-related, disease-specific and extracellular vesicle-based signature associated to outcomes.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for patients:

• WHO2022-defined diagnosis of Hairy Cell Leukemia.
• Age ≥18 years.
• Signed informed consent.

Inclusion criteria for Healthy Donors:

• Age ≥18 years.
• Volunteers in general good health, free from any disease or serious illness.
• Signed informed consent.

Exclusion criteria

• None