Decompression Intervention of Variceal Rebleeding Trial (DIVERT)

National Institutes of Health (NIH)

Status and phase: Completed; Phase 3

Conditions: Liver Cirrhosis; Esophageal and Gastric Varices

Treatments: Procedure: Transjugular Intrahepatic Portosystemic Shunt (TIPS); Procedure: Distal Splenorenal Shunt

Study type: Interventional

Funder types: NIH

Identifiers

NCT00006161

DK50680-02

DIVERT (completed)

Details and patient eligibility

About

The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis.

This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Variceal bleeding secondary to cirrhosis and portal hypertension
• Child's Class A or B cirrhosis of any etiology
• Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy

Exclusion criteria

• Prior shunt procedure
• Portal vein thrombosis
• Polycystic liver disease
• Intractable ascites
• Prior organ transplant
• Any medical intractable disease