Decompressive Cervical Surgery and Hypertension

Peking University

Status: Completed

Conditions: Hypertension; Myelopathy, Compressive

Treatments: Procedure: decompressive cervical surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02016768

PUCRP201304

Details and patient eligibility

About

There is a relationship between CSM and hypertension, probably a cause/effect relationship, and investigators term this type of hypertension "cervicogenic hypertension". Abnormally functioning serotonergic pacemaker cells in the dorsal raphe nucleus inappropriately activate and inhibit parts of the central and autonomic nervous systems as part of a chronic stress response, which causes hypertension and migraine. This theory is now being expanded to encompass both CSM and essential hypertension, the idea being that these two conditions are intimately related.

Full description

Cervical spondylotic myelopathy (CSM) and hypertension are both very common diseases in the general population.Investigators have also observed previously hypertensive patients with CSM become normotensive following decompressive cervical surgery and no longer need antihypertensive medications. Both observations are difficult to explain according to current theories of the two diseases.

Enrollment: 50 patients

Sex: All

Ages: 18 to 84 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Established diagnosis of cervical spondylosis myelopathy
• Be at least 18 years of age
• Office-measured systolic BP≧140mmHg
• Ability to adhere to study protocol
• Have signed an approved informed consent form for participation in this study

Exclusion criteria

• Have hypertension secondary to a treatable cause
• Have prior cervical spine surgery
• Are pregnant or contemplating pregnancy during the 3-month follow-up period
• People deny to join the study
• Are unable to comply with protocol requirements
• Are unlikely to survive the protocol follow-up period
• Are enrolled in another concurrent clinical trial
• Visual Analogue Scale≥4

Trial design

50 participants in 1 patient group

operation

Description:

To make decompressive cervical surgery, either anterior cervical discectomy and fusion or posterior laminoplasty on the patients suffering from cervical spondylotic myelopathy and hypertension.

Treatment:

Procedure: decompressive cervical surgery