Decontamination Methods in the Treatment of Peri-implantitis

Research Centre for Medical Genetics, Russian Federation

Status: Completed

Conditions: Peri-implantitis

Treatments: Drug: Octenisept; Procedure: Glycine Powder; Procedure: Sodium Bicarbonate Powder; Drug: Chlorhexidine; Procedure: Erythritol Powder; Drug: Miramistin

Study type: Interventional

Funder types: Other

Identifiers

NCT07500844

1/21

Details and patient eligibility

About

The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is:

Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.

Full description

This is a prospective, interventional study involving 48 patients diagnosed with peri-implantitis.

Groups: Participants were allocated into three groups (n=16 per group) to receive one of three treatment combinations.

Group 1: Treatment with Miramistin solution (0.01%) and air-polishing with sodium bicarbonate powder.

Group 2: Treatment with Chlorhexidine solution (0.05%) and air-polishing with erythritol powder.

Group 3: Treatment with Octenisept solution and air-polishing with glycine powder.

Intervention: Each patient received the assigned combination treatment at intervals of 7-10 days over one month.

Outcome Measures: Clinical parameters were assessed at baseline, 1 month, and 2.5 months after the start of treatment:

Primary Clinical Outcomes: Changes in probing depth (PD) and bleeding on probing (BOP).

Secondary Clinical Outcomes: Changes in plaque index (PLI), gingival index (GI), presence of suppuration, and radiographic bone loss (assessed via periapical radiographs and cone-beam computed tomography (CBCT)). The need for subsequent surgical intervention was also recorded.

Enrollment: 64 patients

Sex: All

Ages: 21 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 21 and 75 years
• Presence of at least one dental implant
• Diagnosis of peri-implantitis defined as probing depth ≥ 6 mm and radiographic bone loss ≥ 3 mm apical to the most coronal portion of the intraosseous part of the implant
• Ability to attend follow-up appointments for up to 3 months
• Willingness to participate and provide written informed consent

Exclusion criteria

• Presence of systemic diseases in a decompensated stage (e.g., uncontrolled diabetes mellitus, severe cardiovascular disease, psychotic disorders, active oncological disease)
• Current or prior use of immunosuppressive drugs, bisphosphonates, high-dose corticosteroids, antipsychotics, or other medications known to negatively affect peri-implant tissue regeneration and healing
• Pregnancy or lactation
• Unwillingness or inability to comply with study procedures
• Peri-implantitis requiring immediate surgical intervention or implant removal at baseline

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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64 participants in 3 patient groups

Miramistin + Sodium Bicarbonate

Experimental group

Description:

Participants in this arm receive non-surgical treatment for peri-implantitis using a combination of Miramistin antiseptic solution (0.01%) and air-polishing with sodium bicarbonate powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.

Treatment:

Drug: Miramistin

Procedure: Sodium Bicarbonate Powder

Chlorhexidine + Erythritol

Active Comparator group

Description:

Participants in this arm receive non-surgical treatment for peri-implantitis using a combination of Chlorhexidine antiseptic solution (0.05%) and air-polishing with erythritol powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.

Treatment:

Procedure: Erythritol Powder

Drug: Chlorhexidine

Octenisept + Glycine

Active Comparator group

Description:

Participants in this arm receive non-surgical treatment for peri-implantitis using a combination of Octenisept antiseptic solution and air-polishing with glycine powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.

Treatment:

Procedure: Glycine Powder

Drug: Octenisept