Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks (DACODEC)

R

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Decompression Sickness

Treatments

Other: 20 meters air dive

Study type

Interventional

Funder types

Other

Identifiers

NCT02736006
RB15.173 (DACODEC)

Details and patient eligibility

About

Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities. As a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in DCS. Individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.

Full description

2 groups of occupational divers will be separated after a fitness medical examination by regarding DLCO decrease or not. The divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. Venous bubbles will be detected by precordial Doppler 30 minutes after the dive. In association with this Doppler, Flow Mediated Dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.

Enrollment

16 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Be professional and voluntary diver
  • Man or woman aged 18 years or older
  • Diffusing Lung Capacity for Carbon Monoxide measured beforehand in the study
  • No medical contraindication for hyperbaric
  • No hyperbaric constraint in 3 days before the dive
  • No prior Decompression sickness
  • Not to follow medicinal treatment modifying the vascular endothelial and/or the coagulation and/or the respiratory function
  • Patient affiliated to social security
  • Informed and signed

Exclusion criteria

  • Concomitant pathology identified by the Investigator, justifying a contraindication for hyperbaric
  • Pregnant and nursing mothers
  • Patient who refuse to sign consent form

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

16 participants in 1 patient group

20 meters air dive
Experimental group
Treatment:
Other: 20 meters air dive

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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