DECT Ventilation Imaging

University Hospital, Strasbourg, France

Status: Terminated

Conditions: With Recent (Less Than 1 Month) Respiratory Functional Explorations; Single of Bilateral Lung Transplant; From 5 Months Onwards; Potentially Operable Lung Tumor; For Oncologic Patients; With a Recent (Less Than 1 Month) VQ Scan; For Lung Transplant Recipients

Treatments: Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media

Study type: Interventional

Funder types: Other

Identifiers

NCT02377518

5601

Details and patient eligibility

About

Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation.

Two different clinical situations will be tested :

• Prediction of postoperative pulmonary function for oncologic patients
• Detection of Bronchiolitis Obliterans in lung transplant recipients.

Enrollment: 10 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

For oncologic patients :

• Potentially operable lung tumor
• With a recent (less than 1 month) V/Q scan

For lung transplant recipients :

• Single of bilateral lung transplant
• From 5 months onwards
• With recent (less than 1 month) respiratory functional explorations

Exclusion criteria

• Impossibility to follow simple orders or control one's respiration
• Known Krypton hypersensitivity
• History of malignant hyperthermia
• Increased intracranial pressure
• Minors
• Pregnant Women

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

10 participants in 2 patient groups

oncologic patients

Experimental group

Description:

Prediction of postoperative pulmonary function. Patients with an operable lung cancer: dual energy computed tomography with Krypton will be tested to estimate the postoperative FEV1

Treatment:

Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media

lung transplant recipients

Experimental group

Description:

Detection of BOS 6 months+ lung transplant recipients will be tested using dual energy computed tomography with Krypton, with acquisition in the end-inspiratory and end-expiratory phase, in search of regional air trapping.

Treatment:

Radiation: Single source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media