Deep Brain Stimulation and Parkinson's Disease (SCP TCI NIRS)

Centre Hospitalier Universitaire, Amiens

Status and phase: Completed; Early Phase 1

Conditions: Parkinson Disease

Treatments: Device: NIRS EEG HR recording

Study type: Interventional

Funder types: Other

Identifiers

NCT02795663

PI2013_843_0016

Details and patient eligibility

About

• Background : Deep brain stimulation of SubThalamic Nucleus (STN-DBS) is an effective treatment for a large variety of movement disorders. However, the efficacy of STN-DBS relies on unclear mechanisms.
• Purpose: In this study, using optical imaging, the investigators will evaluate the cortical hemodynamic changes induced by STN-DBS of parkinsonian patients during motor task and delay discounting task. the investigators will perform an optical imaging study using Near-InfraRed Spectroscopy (NIRS) in a parkinsonian patient after STN-DBS. The investigators will measure bilateral local cortical hemodynamic changes under "On" and "Off" stimulation conditions and during a motor task (left hand movement) and delay discounting task Relative concentration changes of oxy-Hb, deoxy-Hb, and total Hb will be continuously analyze.
• Primary outcome: Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total Hb) under " on " and " off " stimulation during a motor task.

Enrollment: 15 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting Parkinson disease and treated by STN-DBS.
• For comparison patients: Patients treated by DBS in other target.

Exclusion criteria

• Patients who cannot be treated by DBS

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

parkinson's patient stimulated at STN level

Experimental group

Description:

15 parkinson's disease patients stimulated at STN level NIRS EEG HR recording

Treatment:

Device: NIRS EEG HR recording

non STN

Experimental group

Description:

5 Parkinson's Disease patients who received stimulation in another target that the STN NIRS EEG HR recording

Treatment:

Device: NIRS EEG HR recording

control

Experimental group

Description:

20 control patients undergoing DBS for the treatment of OCD NIRS EEG HR recording

Treatment:

Device: NIRS EEG HR recording