Deep Brain Stimulation in Severe Obsessive-compulsive Disorder (DBS in OCD)

University Hospital, Umeå

Status: Completed

Conditions: Obsessive-Compulsive Disorder

Treatments: Device: Deep brain stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04919785

08-090M

Details and patient eligibility

About

Deep brain stimulation is an established treatment for movement disorders. New indications for deep brain stimulation are under investigation, among them severe and treatment-resistant obsessive-compulsive disorder. Here, the investigators investigate clinical outcomes, safety and mechanism of action of DBS in the BNST in a series of 11 participants with severe therapy-refractory OCD.

Enrollment: 11 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe OCD according to the Diagnostic and Statistical Manual of Mental Disorders: DSM-IV
• YBOCS score of at least 25/40
• Disease duration of ≥5 years with persistent disabling symptoms despite adequate trials with at least 3 different serotonergic acting antidepressants, augmentation with antipsychotics, and CBT
• Only patients between 18 and 65 years of age who could understand and comply with instructions and provide their own written consent.

Exclusion criteria

• Current psychotic or substance abuse disorder
• Clinically significant medical disorder, or previous brain surgery

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Deep brain stimulation

Experimental group

Description:

Deep brain stimulation in the bed nucleus of stria terminalis

Treatment:

Device: Deep brain stimulation