Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction

Shanghai Jiao Tong University

Status

Unknown

Conditions

Treatment Methamphetamine Addiction

Treatments

Procedure: Bilateral surgical implantation of DBS system to NAc

Study type

Interventional

Funder types

Other

Identifiers

NCT03347474

2018-10-25 DBS-NAc Meth

Details and patient eligibility

About

The main objective of this study is to assess the efficacy of bilateral deep brain stimulation (DBS) of the Nucleus Accumbens(NAc) as a novel treatment in severe methamphetamine addiction. Our hypothesis is that bilateral DBS of the NAc will significantly reduce the craving for methamphetamine.

Enrollment

10 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

DSM-IV-TR diagnosis of Drug addiction disorder;
Age 18-65 years old;
Proficiency in Mandarin language;
Failure to detox more than three times;
Capacity to provide informed consent (understanding of the study purpose and methods);

Exclusion criteria

Multidrug abuse and formation of addiction;
Serious and unstable organic diseases (e.g. unstable coronal heart disease);
Any history of seizure disorder or hemorrhagic stroke;
Past stereotactic neurosurgical intervention;
Neurological disease (Abnormal PET-CT, MRI, EEG)
Contraindications of MRI-examination, e.g. implanted cardiac pacemaker/ heart defibrillator;
Contraindications of stereotactic intervention, e.g. increased bleeding disposition, cerebrovascular diseases (e.g. arteriovenous malfunction, aneurysms, systemic vascular diseases);
HIV positive;
Pregnancy and/or lactation;