Deep Brain Stimulation Therapy and Intestinal Microbiota

Nanjing Medical University

Status: Unknown

Conditions: Deep Brain Stimulation; Gastrointestinal Microbiome

Study type: Observational

Funder types: Other

Identifiers

NCT04855344

Ling Zhou

Details and patient eligibility

About

This study aims to observe the changes of intestinal microbiota after deep brain stimulation (DBS) therapy for Parkinson's disease, and explore the role of intestinal microbiota in the neuroprotective effect of DBS.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. > 18 years of age;
2. Primary Parkinson's disease diagnosed according to British Brain Bank criteria (Hoehn and Yahr);
3. Deep brain stimulator therapy;
4. Sign the informed consent.

Exclusion criteria

1. Use of probiotics or probiotics during the study;
2. Use antibiotics against intestinal bacteria at present or within the last 1 month;
3. With cognitive dysfunction or mental illness;
4. With severe diseases or is not expected to survive for more than a year;
5. A history of gastrointestinal surgery;
6. AIDS patients, hepatitis B/C positive.