Deep Inferior Epigastric Artery Flap for Breast Reconstruction

Chiayi Christian Hospital

Status: Completed

Conditions: Breast Cancer; Infections; Anti-Infectives Adverse Reaction; Perforator Flap

Treatments: Drug: prophylactic antibiotics duration

Study type: Observational

Funder types: Other

Identifiers

NCT05088239

CYCH-IRB No.2020092

Details and patient eligibility

About

Background: There is no consensus on the duration of prophylactic antibiotics for autologous breast reconstruction after mastectomy. We try to standardize prophylactic antibiotics use during breast reconstruction with deep inferior epigastric perforator flap following mastectomy.

Methods: This retrospective case series involved 108 patients who underwent immediate breast reconstruction with deep inferior epigastric perforator flap in Ditmanson Medical Foundation Chia-Yi Christian Hospital between 2012 and 2019. Patients were divided into three groups based on prophylactic antibiotic duration: 1 day, 3 days and >7 days for patients with drains Data were analyzed between January and April, 2021.

Enrollment: 108 patients

Sex: Female

Ages: 24 to 63 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• This retrospective study involved 108 patients who underwent immediate DIEP flap breast reconstruction after unilateral or bilateral mastectomy at the Ditmanson Medical Foundation Chia-Yi Christian Hospital between 2012 and 2019.

Exclusion criteria

• Age < 20 years old.

Trial design

108 participants in 3 patient groups

PAD

Description:

In prophylactic antibiotics for drain group (PAD) (n = 15), prophylactic cefazolin 1000 mg was given 30 minutes before surgery, every 4 hours in the peri-operative period, and every 6 hours in the post-operative for 10-14 days when the drains were removed from the breast and abdomen.

Treatment:

Drug: prophylactic antibiotics duration

PA3

Description:

In the 3-day prophylactic antibiotics group (PA3) (n = 11), prophylactic cefazolin 1000 mg was given 30 minutes before surgery, every 4 hours in peri-operative period, and 6-hourly thereafter for 3 days.

Treatment:

Drug: prophylactic antibiotics duration

PA1

Description:

In the 1-day prophylactic antibiotics group (PA1) (n = 82), patients received prophylactic cefazolin 1000 mg 30 minutes before surgery, every 4 hours in the peri-operative period, and every 6 hours in the post-operative period and antibiotics were discontinued within 24 hours of surgery.

Treatment:

Drug: prophylactic antibiotics duration