Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer

Shu lian Wang

Status: Unknown

Conditions: Breast Cancer; Cardiac Event

Treatments: Device: Deep inspiration breath-hold technique

Study type: Observational

Funder types: Other

Identifiers

NCT05200078

2020-2-4023

Details and patient eligibility

About

Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.

Full description

Women with left-sided breast cancer undergo hypofractionated RT at either free-breathing or deep inspiration breath-hold. The incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.

Enrollment: 166 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary left-sided breast cancer post surgery
• Planning for adjuvant breast/chest wall +-RNI

Exclusion criteria

• History of cardiovascular disease
• Previous chest radiation
• Bilateral breast cancers

Trial design

166 participants in 2 patient groups

Radiotherapy at free-breathing

Description:

breast/chest wall+-RNI 43.5Gy/15f/3w（tumor bed 49.5Gy/15f/3w) delivered at free-breathing

Radiotherapy at deep inspiration breath-hold

Description:

breast/chest wall+-RNI 43.5Gy/15f/3w（tumor bed 49.5Gy/15f/3w) delivered at deep inspiration breath-hold

Treatment:

Device: Deep inspiration breath-hold technique