Deep Learning for Histopathological Classification and Prognostication of Gynaecologic Smooth Muscle Tumours (STUMP)

Institut Bergonié

Status: Enrolling

Conditions: Stump

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06540846

IB2023-STUMP

Details and patient eligibility

About

Smooth muscle tumors of the uterus that do not fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas) are called STUMP (smooth muscle tumor of uncertain malignant potential). A potential solution to this problem could be the application of predictive models using artificial intelligence (AI) to aid in the histopathological classification and prognosis of gynecological smooth muscle tumors. Deep learning using convolutional neural networks represents a specific class of machine learning, in which predictive models are trained by considering small groups of pixels in digital images and iteratively identifying salient features. In this study, we aim to develop deep learning models capable of accurately subclassifying and predicting the prognosis of gynecological smooth muscle tumors, based on histopathological features of hematoxylin and eosin (H&E) slides. The aim is to develop a diagnostic and prognostic algorithm to help pathologists better classify and diagnose uterine smooth muscle tumors and predict their clinical course.

Enrollment: 392 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a diagnosis of uterine smooth muscle tumors (leiomyomas, smooth muscle tumors of uncertain malignancy and leiomyosarcomas), registered in the RRePS database and/or treated at Institut Bergonié or one of the participating centers.
• Histopathological material available (kerosene blocks and/or slides).
• The follow-up (outcome) is required for each LMS/ STUMP.

Exclusion criteria

• na

Trial design

392 participants in 2 patient groups

STUMP cohort

Description:

Smooth muscle tumors of the uterus that do not fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas) : smooth muscle tumor of uncertain malignant potential

Treatment:

Other: No intervention

Leiomyoma-leiomyosarcoma

Description:

Smooth muscle tumors of the uterus that do fit the diagnostic criteria of benignity (such as leiomyomas) or malignancy (such as leiomyosarcomas)

Treatment:

Other: No intervention