Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy

Anqing Municipal Hospital

Status: Enrolling

Conditions: Laparoscopy; Neuromuscular Blockade

Treatments: Device: standard-pressure pneumoperitoneum; Device: low-pressure pneumoperitoneum

Study type: Interventional

Funder types: Other

Identifiers

NCT06469866

xuzhang520

Details and patient eligibility

About

BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB. The present study investigated deep NMB could improve the quality of recovery after laparoscopic hysterectomy

METHODS: seventy-two women with elective laparoscopic hysterectomy were randomly divided into 2 groups: Patients in group A received low-pressure pneumoperitoneum (LPP), which was set at 8-10 mmHg with deep NMB. Patients in group B received standard-pressure pneumoperitoneum (SPP), which was set at 12-14 mmHg with moderate NMB. Primary outcome was the quality of recovery (QoR-15) at 1 day after sugery. The secondary outcomes included postoperative pain, surgical condition, incidence of shoulder pain, the incidence of rescue analgesic drug use, cumulative dose of analgesics, time of first flatus, post-operative nausea and vomiting, time of tracheal tube removal.

Enrollment: 72 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅲ
• Scheduled for elective laparoscopic hysterectomy

Exclusion criteria

• Inability to give informed consent
• BMI >35
• Renal or hepatic insufficiency
• History of preoperative psychiatric
• Previous surgery at procedure site
• Neuromuscular disease, pregnancy, and contraindications to study medications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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72 participants in 2 patient groups

low-pressure pneumoperitoneum (LPP) with deep NMB affect quality of recovery

Experimental group

Description:

low-pressure pneumoperitoneum (LPP) with deep NMB.

Treatment:

Device: low-pressure pneumoperitoneum

Device: standard-pressure pneumoperitoneum

standard-pressure pneumoperitoneum (SPP) with moderate NMB affect quality of recovery

Experimental group

Description:

standard-pressure pneumoperitoneum (SPP) with moderate NMB.

Treatment:

Device: low-pressure pneumoperitoneum

Device: standard-pressure pneumoperitoneum