Deep Neuromuscular Blockade on Postoperative Pain

Seoul National University

Status: Enrolling

Conditions: Neuromuscular Blockade

Treatments: Drug: rocuronium 0.2 mg/kg/hr continuous infusion; Drug: rocuronium 0.6 mg/kg/hr continuous infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT06679569

2410-015-1575

Details and patient eligibility

About

This study aims to investigate the impact of varying degrees of neuromuscular blockade on postoperative pain in pediatric patients aged over 2 months to under 7 years undergoing laparoscopic surgery under general anesthesia.

Enrollment: 106 estimated patients

Sex: All

Ages: 2 months to 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric patients aged over 2 months to under 7 years scheduled for laparoscopic surgery under general anesthesia.
• American Society of Anesthesiologists (ASA) Physical Status Classification I, II, or III.

Exclusion criteria

• Patients undergoing emergency surgery.
• Patients with chronic pain or currently taking analgesics for chronic pain.
• Known hypersensitivity to general anesthetic agents or analgesics.
• Patients with underlying cardiovascular disease.
• Patients with neuromuscular disorders.
• Any other condition that, in the investigator's judgment, would make the patient unsuitable for participation in the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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106 participants in 2 patient groups

moderate neuromuscular blockade

Active Comparator group

Treatment:

Drug: rocuronium 0.2 mg/kg/hr continuous infusion

deep neuromuscular blockade

Experimental group

Treatment:

Drug: rocuronium 0.6 mg/kg/hr continuous infusion