Deep rTMS in Parkinson Disease Pain Syndromes

U

University of Sao Paulo

Status

Unknown

Conditions

Parkinson Disease
Pain

Treatments

Device: deep rTMS
Device: placebo deep rTMS

Study type

Interventional

Funder types

Other

Identifiers

NCT03504748
VRBDCA

Details and patient eligibility

About

Pain is the most prevalent non-motor symptom in Parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. By this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to Parkinson disease. This technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Parkinson disease
  • Signed term of informed consent
  • Parkinsson disease related pain

Exclusion criteria

  • Trauma of Skull, epilepsy don't treated
  • Use of medications decrease the seizure threshold
  • Patients in use of drugs, how cocaine and alcohol
  • neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure)
  • Pregnant or lacting women
  • Moderate or severe cognitive impairment

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

30 participants in 2 patient groups

deep rTMS-active doble coil
Active Comparator group
Description:
patients undergoing of deep rTMS real with doble coil
Treatment:
Device: deep rTMS
deep rTMS-sham
Sham Comparator group
Description:
patients undergoing to placebo deep rTMS
Treatment:
Device: placebo deep rTMS

Trial contacts and locations

1

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Central trial contact

Daniel MD Ciampi, Phd; Victor MD Barboza, PhD student

Data sourced from clinicaltrials.gov

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