Deep rTMS in Parkinson Disease Pain Syndromes

University of Sao Paulo

Status: Unknown

Conditions: Parkinson Disease; Pain

Treatments: Device: deep rTMS; Device: placebo deep rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT03504748

VRBDCA

Details and patient eligibility

About

Pain is the most prevalent non-motor symptom in Parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. By this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to Parkinson disease. This technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson disease
• Signed term of informed consent
• Parkinsson disease related pain

Exclusion criteria

• Trauma of Skull, epilepsy don't treated
• Use of medications decrease the seizure threshold
• Patients in use of drugs, how cocaine and alcohol
• neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure)
• Pregnant or lacting women
• Moderate or severe cognitive impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

deep rTMS-active doble coil

Active Comparator group

Description:

patients undergoing of deep rTMS real with doble coil

Treatment:

Device: deep rTMS

deep rTMS-sham

Sham Comparator group

Description:

patients undergoing to placebo deep rTMS

Treatment:

Device: placebo deep rTMS