Deep vs Moderate Neuromuscular Blockade in Day Case Laparoscopic Cholecystectomy.

Wahba bakhet

Status and phase: Completed; Phase 4

Conditions: Muscle Relaxation

Treatments: Drug: Rocuronium Bromide

Study type: Interventional

Funder types: Other

Identifiers

NCT03881423

wbakhet

Details and patient eligibility

About

Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay .

Full description

Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay.

The surgeon requires a good surgical conditions to perform the operation, whereas the anesthesiologist is concerned with postoperative QOR. Pneumoperitoneium -associated expansion of the abdominal cavity during LC is related to postoperative pain.

and other physiological changes, affecting the postoperative QOR negatively . Poor postoperative QOR leads to prolonged hospital stay .

Enrollment: 80 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA I and II

Exclusion criteria

• Neuromuscular disorders

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups

Deep block

Active Comparator group

Description:

In the deep NMB-group, a PTC of 1 to 2 twitches was maintained, and NMB was reversed with sugammadex at the end of surgery.

Treatment:

Drug: Rocuronium Bromide

Moderate block

Active Comparator group

Description:

In the moderate NMB group, a TOF count of 1 to 2 was maintained and NMB was reversed with a combination of neostigmine and glycopyrolate at the end of surgery.

Treatment:

Drug: Rocuronium Bromide