Deep vs Moderate Neuromuscular Blocks on Remifentanil for Laparoscopic Gastrectomy

A

Ajou University School of Medicine

Status

Completed

Conditions

Gastric Cancer

Treatments

Drug: Sugammadex
Drug: Neostigmine + glycopyrate

Study type

Interventional

Funder types

Other

Identifiers

NCT04205097
AJIRB-MED-THE-19-217

Details and patient eligibility

About

The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.

Enrollment

120 patients

Sex

All

Ages

19 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of gastric cancer Scheduled laparoscopic gastrectomy

Exclusion criteria

Patients refusal to consent Hyperbilirubinemia Chronic pain Opioid abuse Incurrent infective status Peripheral vascular disease

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

120 participants in 2 patient groups, including a placebo group

Moderate NMB group
Placebo Comparator group
Description:
maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg
Treatment:
Drug: Neostigmine + glycopyrate
Deep NMB group
Experimental group
Description:
maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 2~4 mg/kg
Treatment:
Drug: Sugammadex

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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