Deep vs Moderate Neuromuscular Blocks on Remifentanil for Laparoscopic Gastrectomy

Ajou University School of Medicine

Status: Completed

Conditions: Gastric Cancer

Treatments: Drug: Sugammadex; Drug: Neostigmine + glycopyrate

Study type: Interventional

Funder types: Other

Identifiers

NCT04205097

AJIRB-MED-THE-19-217

Details and patient eligibility

About

The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.

Enrollment: 120 patients

Sex: All

Ages: 19 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of gastric cancer Scheduled laparoscopic gastrectomy

Exclusion criteria

• Patients refusal to consent Hyperbilirubinemia Chronic pain Opioid abuse Incurrent infective status Peripheral vascular disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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120 participants in 2 patient groups, including a placebo group

Moderate NMB group

Placebo Comparator group

Description:

maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg

Treatment:

Drug: Neostigmine + glycopyrate

Deep NMB group

Experimental group

Description:

maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 2~4 mg/kg

Treatment:

Drug: Sugammadex