Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality (pet-ct)

Hospital Sao Rafael

Status: Completed

Conditions: Secondary Neoplasm Malignant and Unspecified Lymph Nodes; Malignant Neoplasm of Bronchus and Lung; Non-Hodgkin Lymphoma, Follicular (Nodular); Hodgkin Disease; Malignant Neoplasm of Colon; Malignant Neoplasm of Small Intestine; Malignant Neoplasm of Breast; Malignant Melanoma of the Skin

Treatments: Other: Image quantify

Study type: Observational

Funder types: Other

Identifiers

NCT02378337

27558714.4.0000.0048

Details and patient eligibility

About

Identify the best combination of predictive variables that influence ionizing radiation dose and improved image quality through analysis and quantification of PET-CT images in simulators and patients.

Enrollment: 335 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers;
• Both genders;
• Age over 18 years;
• Clinical indication for PET-CT scan.

Exclusion criteria

• Pregnant women;
• Patients who have lesions in the liver metabolically active whether primary or metastatic;
• Patients with movement difficulties.

Trial design

335 participants in 2 patient groups

Retrospective development cohort

Description:

A total of 85 18F-FDG-PET adult studies were gathered over a 3-month period and retrospectively evaluated.

Treatment:

Other: Image quantify

Prospective validation cohort

Description:

To verify the application of methodology in clinical routine, we conducted a second phase of the study prospectively in 250 subjects (phase 2) using inclusion and exclusion criteria of the retrospective study (phase 1).

Treatment:

Other: Image quantify