Defining Robust Predictors of Chemotherapy Related Cardiotoxicity

University College London (UCL)

Status: Enrolling

Conditions: Cardiotoxicity; Gastrointestinal Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT05159479

140342

Details and patient eligibility

About

Observational prospective cohort study designed for patients with gastrointestinal cancers receiving a fluoropyrimidine based chemotherapy regimen.

Full description

All enrolled participants will undergo baseline cardiovascular risk assessment (using QRISK3 and SCORE 2 risk calculators), cardiac, oncological and medication history. All participants will have serial cardiac symptom assessment, 12 lead ECG and cardiac biomarker assessments(high sensitivity troponin T and NT pro BNP) at baseline, on completion of the first cycle of treatment and post completion of treatment. Participants will be followed up for the development of cardiotoxicity.

Enrollment: 600 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18
• Consented to receive fluoropyrimidine chemotherapy for GI malignancies (gastro-oesophageal, colorectal, pancreatic)
• Capacity to provide consent

Exclusion criteria

• Age <18
• Lacking capacity to consent