Defining the Sympathetic Skin Response of Migraineurs in the Facial Area

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Migraine Disorders

Treatments: Other: Visual stimulation; Other: Auditory stimulation; Other: Pain stimulation; Other: Mental stress

Study type: Observational

Funder types: Other

Identifiers

NCT03772860

HYMC-113-18

Details and patient eligibility

About

The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation, auditory stimulation and a mathematical challenge), and recording sympathetic skin response in the facial area.

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers with no history of any kind of recurrent headache
• Migraine patients according to ICH3 criteria
• Migraine patients with more than 1 attack per month

Exclusion criteria

• Patients with other heart or neurologic diseases
• Patients with hearing or visual decline
• Patients taking medication that effects the sympathetic system (except those taking beta blockers for migraine treatment)

Trial design

70 participants in 4 patient groups

Healthy volunteers

Description:

Healthy volunteers will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress

Treatment:

Other: Auditory stimulation

Other: Pain stimulation

Other: Visual stimulation

Other: Mental stress

Left headache

Description:

Migraine patients with mostly left sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress

Treatment:

Other: Auditory stimulation

Other: Pain stimulation

Other: Visual stimulation

Other: Mental stress

Right headache

Description:

Migraine patients with mostly right sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress

Treatment:

Other: Auditory stimulation

Other: Pain stimulation

Other: Visual stimulation

Other: Mental stress

Bilateral headache

Description:

Migraine patients without a dominant side headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress

Treatment:

Other: Auditory stimulation

Other: Pain stimulation

Other: Visual stimulation

Other: Mental stress