Definitive (Chemo)Radiotherapy for Patients With Esophageal Cancer - 3JECROG R-01

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Radiotherapy Side Effect; Chemotherapy Effect; Esophagus Cancer; Chemoradiation

Study type: Observational

Funder types: Other

Identifiers

NCT03298204

3JECROG R-01

Details and patient eligibility

About

The aim of this observational study is to retrospectively collect survival data for 3000 primary esophageal cancer patients from multicenter between January 2000 to present. Based on a Cox model, we want to develope a nomogram that predicts local recurrence, distant metastases, and survival for patients treated with radiotherapy or chemoradiotherapy with or without chemotherapy.

Enrollment: 2,762 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed squamous cell carcinoma, adenocarcinoma of the esophageal or esophagogastric junction Unresectable or potentially resectable tumor (cT3-4N0-1M0-M1b, without visceral metastasis, according to AJCC 6th) based on standard primary staging by EUS and CT
• Age>18 years
• No distant metastasis other than supraclavicular lymph nodes
• No prior history of thoracic radiation
• Patients must have normal organ and marrow function as defined below: Leukocytes: greater than or equal to 3,500 G/L; Platelets: greater than or equal to 100,000/mm3 .Hemoglobin:greater than or equal to 10g/L .Total bilirubin: within normal institutional limits; AST/ALT: less than or equal to 1.5 times the upper limit; Creatinine within normal upper limits

Exclusion criteria

• Patients with other cancer history except cervical carcinoma in situ and non-malignant melanoma skin cancer during 5 years before diagnosis of esophageal cancer
• Pregnant or lactating females
• Contraindication for radiotherapy or chemotherapy

Trial design

2,762 participants in 3 patient groups

Chemoradiotherapy

Chemoradiotherapy following chemotherapy

Chemoradiotherapy followed by chemotherapy