Definitive Radiation for High-Risk Spine Metastases

Stony Brook University

Status and phase

Enrolling

Phase 2

Conditions

Metastatic Tumor

Metastatic Cancer

Metastasis

Metastatic Tumor to the Spine

Metastatic Tumor of Bone

Metastatic Breast Cancer

Spine Metastases

Metastatic Lung Cancer

Treatments

Radiation: SBRT to the spine

Study type

Interventional

Funder types

Other

Identifiers

NCT06165419

SBU-RT-MESCC

IRB2023-00421 (Other Identifier)

Details and patient eligibility

About

This study is looking at whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy only and avoid a large spine surgery

Enrollment

26 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Eligible patients must have:

Any pathologically proven solid tumor diagnosis not of central nervous system origin with radiographic or pathologic evidence of metastatic disease
Metastatic spine involvement documented by imaging
Involvement of maximum 3 contiguous vertebral bodies at the index site
Intact neurologic function, or only minor neurologic deficits with muscle strength greater or equal to 4 out of 5 with or without steroids
An evaluation by an radiation oncology and orthopedic spine/neurosurgery attending
ECOG Performance Status of 0-3

Patients are ineligible if they have:

An unstable spine defined as a Spinal Instability Neoplastic Score (SINS) greater than 12
Had previous surgery or radiation to address the target spinal metastases
Radiosensitive tumors (e.g. small cell lung cancer, lymphoma, multiple myeloma, and germ-cell tumors)