Degarelix Neo-Adjuvant Radical Prostatectomy Trial

University Health Network, Toronto

Status and phase: Completed; Phase 2

Conditions: Prostate Cancer

Treatments: Drug: Casodex; Drug: LHRH Agonist; Drug: Degarelix

Study type: Interventional

Funder types: Other

Identifiers

NCT01674270

DEG_PRE-OP_001

Degarelix Pre-Op

Details and patient eligibility

About

To assess the effect of neo-adjuvant GnRH antagonist, degarelix, versus LHRH agonist on intratumoral levels of androgens.

Enrollment: 35 patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men >18 and =< 75 years of age
• Willing and able to provide informed consent, either alone or with the aid of a translator
• Histologically confirmed prostate cancer as determined by transrectal ultrasound (TRUS) guided prostate biopsy performed within 6 months of study enrolment
• Gleason Score >= 7and/or prostate cancer that is clinical stage T2 disease.
• Candidates for open radical prostatectomy considered surgically resectable by urologic evaluation
• Normal organ and marrow function as defined by the following criteria:
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

Exclusion criteria

• Previous or current use of hormonal management of prostate cancer (surgical castration or other hormonal manipulation, including GnRH receptor agonists, GnRH receptor antagonists, anti-androgens, estrogens, megestrol acetate, and ketoconazole)
• History of receiving radiation to the pelvic area.
• Previously received therapy with 5-alpha reductase inhibitors finasteride and/or dutasteride 4 weeks prior to randomization.
• History of bilateral orchiectomy, adrenalectomy, or hypophysectomy.
• History of severe untreated asthma, anaphylactic reactions, or severe urticaria and/or angioedema.
• Known hypersensitivity towards any component of the investigational medicinal product or Casodex (bicalutamide) or their excipients.
• Marked baseline prolongation of QT/QTcF interval (e.g. repeated demonstration of a QTcF interval >450 ms).
• History of risk factors for Torsade de Pointes ventricular arrhythmias (e.g. heart failure, hypokalemia, or family history of Long QT Syndrome).
• Previous history or presence of another malignancy, other than prostate cancer or treated squamous / basal cell carcinoma of the skin, within the last five years.
• Clinically significant laboratory abnormalities (e.g. severe renal or hepatic impairment) which in the judgment of the Investigator would affect the patient's health or the outcome of the trial.
• Clinically significant disorder (other than prostate cancer) including, but not limited to, renal, haematological, gastrointestinal, endocrine, cardiac, neurological, or psychiatric disease, and alcohol or drug abuse or any other condition, which may affect the patient's health or the outcome of the trial as judged by the Investigator.
• Use of natural medicines thought to have endocrine effects on prostate cancer (e.g. saw palmetto and St. John's Wort) 4 weeks prior to randomization.
• Mental incapacity or language barrier precluding adequate understanding or co operation.
• Use of an investigational drug within the last 28 days preceding the Screening Visit or longer if considered to possibly influence the outcome of the current trial.
• Previously participated in any degarelix trial.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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35 participants in 3 patient groups

Degarelix

Experimental group

Description:

Degarelix Alone

Treatment:

Drug: Degarelix

Degarelix + Casodex

Experimental group

Description:

Degarelix and Casodex

Treatment:

Drug: Casodex

Drug: Degarelix

LHRH Agonist + Casodex

Active Comparator group

Description:

LHRH Agonist and Casodex

Treatment:

Drug: Casodex

Drug: LHRH Agonist