Degradation of the Anorexic Hormone Peptide YY

Hvidovre University Hospital

Status and phase: Completed; Early Phase 1

Conditions: Healthy

Treatments: Biological: PYY1-36 infusion; Biological: PYY3-36 infusion; Biological: PYY1-36 + sitagliptin; Biological: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02493959

STKBM-PI14

Details and patient eligibility

About

Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Normal BMI (18.5-25kg/m2)

Exclusion criteria

• Diabetes Mellitus
• Gastric bypass
• Non-caucasian
• Height changes >3 kg within last two months
• Hemoglobin < 7.6 mmol/l
• Chronic disease
• Smoking
• Regularly use of medicine
• Drug abuse

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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8 participants in 1 patient group

PYY infusion

Experimental group

Description:

IV infusion on 4 separate days of PYY or saline in Healthy, normal-weight men, age 18-50 years

Treatment:

Biological: PYY1-36 infusion

Biological: PYY3-36 infusion

Biological: PYY1-36 + sitagliptin

Biological: placebo