Delayed 18F-FDG PET/CT in Improving Visualization of Brain Tumors in Patients With Glioblastoma

Jonsson Comprehensive Cancer Center

Status: Withdrawn

Conditions: Glioblastoma; Glioma

Treatments: Procedure: Computed Tomography; Procedure: Positron Emission Tomography; Radiation: Fludeoxyglucose F-18

Study type: Observational

Funder types: Other

Identifiers

NCT02919332

NCI-2016-01214 (Registry Identifier)

JCCCID655 (Other Identifier)

16-000600 (Other Identifier)

Details and patient eligibility

About

This clinical trial studies how well delayed fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET)/computed tomography (CT) works in improving visualization of brain tumors in patients with glioblastoma. Radiotracers such as 18F-FDG are highly taken up by tumors in the brain and are visualized using PET/CT. Increasing the interval of time between 18F-FDG administration and PET/CT scan may improve the visualization of brain tumors in patients with glioblastoma.

Full description

PRIMARY OBJECTIVES:

I. To improve the visualization/delineation of glioblastoma lesions using delayed 18F-FDG PET/CT imaging.

OUTLINE:

Patients receive fludeoxyglucose F-18 intravenously (IV). Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection.

Note:

Standard Uptake Value (SUV) is defined for state-of-the art PET/CT scanners as Standardized uptake values = count activity per ml within region of interest (MBq/ml)/[injected dose (MBq)/body weight (kgx1000)]

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with histologically proven high grade glioma scheduled for 18F-FDG PET/CT

Exclusion criteria

• Severe psychiatric illness
• Inability to give written consent
• Breast feeding/pregnancy

Trial design

0 participants in 1 patient group

Diagnostic (18F-FDG PET/CT)

Description:

Patients receive fludeoxyglucose F-18 IV. Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection.

Treatment:

Radiation: Fludeoxyglucose F-18

Procedure: Positron Emission Tomography

Procedure: Computed Tomography