Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension (Decibel)

Region Stockholm

Status: Enrolling

Conditions: Subarachnoid Aneurysm Hemorrhage; Cerebral Vasospasm After Subarachnoid Hemorrhage

Treatments: Drug: Endoluminal Spasmolysis; Drug: Induced hypertension with norepinephrine

Study type: Observational

Funder types: Other

Identifiers

NCT07305922

2025-4055

Details and patient eligibility

About

An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults 18 years or older
• Critical care after subarachnoid haemorrhage
• Aneurysm secured by surgical clipping or endovascular procedure
• Suspected, emerging or established severe cerebral vasospasm

Exclusion criteria

• Anticipated survival less than five days, as determined by treating clinician
• Transcranial Doppler signal too weak
• Pregnancy

Trial design

200 participants in 1 patient group

Patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage

Treatment:

Drug: Induced hypertension with norepinephrine

Drug: Endoluminal Spasmolysis