Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation Conditions (DELiso)

Universitätsklinikum Hamburg-Eppendorf

Status: Not yet enrolling

Conditions: Delirium; Cognitive Impairment; Dementia

Study type: Observational

Funder types: Other

Identifiers

NCT07114458

2024-101313-BO-ff

Details and patient eligibility

About

The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive decline compared to older patients without isolation precautions.

To compare this, every person under isolation precautions is compared to other persons of the same age, gender, comorbidities, frailty status and hospital department. Delirium is assessed twice daily with a screening tool named 3D-CAM and cognitive performance is tested by the MOCA-Test six weeks after discharge from hospital and compared to baseline values which are assessed directly after study enrollment.

The study duration for each patient participating is from the time of enrollment during hospitalization until 6 weeks after hospital discharge.

Full description

Delirium is a common complication in older patients during hospitalization. Its prevention is crucial, as it increases morbidity, mortality, and cognitive impairment. Isolation precautions in hospital may further increase delirium risk due to sensory deprivation and reduced mobility.

This study examines the impact of isolation precautions on delirium and neurocognitive disorders in patients ≥70 years. Delirium screening will occur twice daily, with a six-week post-discharge follow-up.

A prospective cohort study will compare delirium incidence in isolated patients with a matched non-isolated control group (matched for age, gender, Charlson Comorbidity Index, Frailty and hospital department). The 3D Confusion Assessment Method (3D-CAM) will be used for Delirium screening. Follow-up assessments will evaluate cognitive function and quality of life. Data will be collected during hospitalization (Days 1-5) and six weeks post-discharge.

Enrollment: 404 estimated patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: - hospitalized patients

• under isolation precautions for at least 24h
• 70 years and above

Exclusion Criteria: - no informed consent

• intensive care treatment
• life expectancy 14 days or less

Trial design

404 participants in 2 patient groups

Exposition

Description:

Patients under isolation precautions in hospital

Control

Description:

Matched control, no isolation precautions