Delirium and Heart Failure

Ain Shams University

Status: Not yet enrolling

Conditions: Delirium Confusional State; Heart Failure

Treatments: Other: Delirium Rating Scale - Revised-98; Diagnostic Test: blood biomarkers; Other: Comprehensive Geriatric Assessment; Other: the Confusion Assessment Method (CAM test) or CAM-ICU

Study type: Observational

Funder types: Other

Identifiers

NCT07302737

FMASU MD195/2025

Details and patient eligibility

About

Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology. This study aims to compare the predictive value of SII and the TyG ratio among other chemical and physiological biomarkers for diagnosing delirium and detecting its severity in older adults with heart failure. These biomarkers reflect different pathophysiological pathways implicated in delirium, including inflammation, cardiovascular stress, and metabolic dysfunction. By evaluating their individual and combined predictive abilities, this research seeks to identify potential tools for early identification of patients at high risk for delirium

Enrollment: 100 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Heart failure stage C

Exclusion criteria

1. cognitive impairment
2. Major Neurological Conditions: (e.g., stroke, traumatic brain injury).
3. Hematological diseases that affect platelet, neutrophil, and lymphocyte counts.
4. Cardiogenic Shock
5. Sepsis
6. Ongoing Treatment with Immunosuppressants, or corticosteroids

Trial design

100 participants in 2 patient groups

cases

Description:

hospitalized older patients with heart failure and delirium

Treatment:

Other: the Confusion Assessment Method (CAM test) or CAM-ICU

Diagnostic Test: blood biomarkers

Other: Comprehensive Geriatric Assessment

Other: Delirium Rating Scale - Revised-98

controls

Description:

age and gender matched heart failure older patients without delirium

Treatment:

Other: the Confusion Assessment Method (CAM test) or CAM-ICU

Diagnostic Test: blood biomarkers

Other: Comprehensive Geriatric Assessment