Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies

Karolinska Institute

Status: Active, not recruiting

Conditions: Chronic Kidney Disease; Alzheimer Dementia (AD); Cognitive Decline; Cholinergic System; Real World Study; Acute Kidney Injuries; Cholinesterase Inhibitors; Dementia

Treatments: Other: Kidney disease

Study type: Observational

Funder types: Other

Identifiers

NCT07093684

VR Starting grant #2022-01428

Details and patient eligibility

About

Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain. However, few studies have explored how these two conditions are connected in the general population. Understanding this link could help improve care for people living with either or both conditions.

This observational project aims to explore the two-way relationship between kidney disease and dementia. The main questions the investigators want to answer are:

1. Does kidney disease increase the risk or worsen the progression of dementia?
2. Does having dementia increase the risk or worsen the progression of kidney disease (both chronic and acute)?
3. Do reno-protective drugs help protect cognitive decline?
4. Do anti-dementia drugs help preserve kidney function?

To answer these questions, the investigators will analyze data collected over a period of 12 years, including people diagnosed with dementia, kidney disease, or both, using several large Swedish and international health registries:

1. The Swedish Dementia Registry (SveDem)
2. The Stockholm CREAtinine Measurements (SCREAM) project
3. The Swedish Renal Registry (SRR)
4. The GeroCovid Cohort
5. The Registry of Dementia of Girona (ReDeGi)
6. Cognitive impairment cohort from memory clinic, Karolinska University Hospital

This study will apply both traditional and advanced epidemiological methods, including multivariable regression, survival analysis, mixed-effects models, and machine learning (ML) techniques to examine long-term trends and associations.

Enrollment: 200,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Population with dementia (all type) and kidney function measurements/Chronic kidney diagnosis

Exclusion criteria

• Population lack of important baseline and follow-up information such as year of birth and sex.

Trial design

200,000 participants in 2 patient groups

Swedish Dementia Registry (SveDem) Cohort

Description:

SveDem was established in 2007 with the purpose of increasing the quality of dementia care in Sweden. SveDem aims to register all dementia patients in Sweden at the time of dementia diagnosis and includes annual follow-ups. The registry stores data on demographics, living conditions, cognitive evaluation by Mini-Mental State Examination (MMSE), type of dementia, community support and pharmacological management.

Treatment:

Other: Kidney disease

The SCREAM project

Description:

SCREAM is a healthcare utilization cohort of all Stockholm residents that accessed SLL healthcare and had a measurement of serum creatinine in either in- or outpatient care. The database includes 2 million individuals (and \>60 million laboratory tests). The kidney function and other laboratory tests are already collected.