Demineralized Whole-tooth vs Demineralized Particulate Dentin Grafts in Alveolar Ridge Preservation

Cairo University (CU)

Status: Unknown

Conditions: Alveolar Bone Loss

Treatments: Procedure: Alveolar ridge preservation using particulate dentin graft; Procedure: Alveolar ridge preservation using whole-tooth dentin graft

Study type: Interventional

Funder types: Other

Identifiers

NCT05336149

42022

Details and patient eligibility

About

The aim of this trial is to compare whole-tooth vs particulate dentin for their effects in alveolar ridge preservation.

Full description

Extraction of the teeth is still one of the most commonly undertaken procedures in dental practices due to various reasons that render the teeth non-restorable. Following extraction, replacing the lost teeth with a prosthetic alternative that provides for both optimal esthetics and function can be challenging due to the inevitable events of socket healing that results in the reduction in alveolar bone height and width. To overcome these limitations and provide for adequate ridge volume, different bone preservation or augmentation techniques can be utilized with different clinical applications.

Alveolar ridge preservation is a procedure that attempts to reduce bone dimensional changes that naturally take place following tooth extraction. To overcome this problem, various approaches using various grafting materials and/or covering membranes have been proposed with varied success. The extracted tooth is no longer considered as clinical waste, it has been explored as an appropriate source for autogenous graft substitute. This idea emerged due to the shared embryonic origin of bone and teeth as well as the similarities in chemical structure as dentin is composed of 30-35% organic part and 65-70% inorganic part in comparison to alveolar bone, with inorganic and organic parts of 35% and 65% respectively. Both whole-tooth and particulate forms has been utilized for alveolar ridge preservation or augmentation but the superiority of one form over the other is not yet clear.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-restorable tooth indicated for extraction
• single-rooted teeth
• Patients at least 18 years or older
• Motivated patients, agree to sign informed consent and complete the follow-up period

Exclusion criteria

• Pregnant females
• active infection at extraction site
• Smokers
• systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Whole-tooth dentin graft

Experimental group

Description:

The extracted tooth will be prepared as whole-tooth dentin graft and inserted in the extraction socket.

Treatment:

Procedure: Alveolar ridge preservation using whole-tooth dentin graft

Particulate dentin graft

Active Comparator group

Description:

The extracted tooth will be prepared as particulate dentin graft and inserted in the extraction socket.

Treatment:

Procedure: Alveolar ridge preservation using particulate dentin graft