Demographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia Intermedia

HaEmek Medical Center, Israel

Status: Completed

Conditions: Thalassemia

Treatments: Genetic: Laboratory analysis.

Study type: Observational

Funder types: Other

Identifiers

NCT01443312

0047-10-EMC

Details and patient eligibility

About

The definition of Thalassemia Intermedia is not generally accepted and the specific clinical and laboratory characteristics varies between patients. Some patients are blood transfusion dependent and others are occasionally transfused. Also the mutations in the beta globin gene are diverse. Another mutations including mutations in the alfa globin gene and in the xmn1 gene can affect the clinical course of this disease. The purpose of this study is to summarize the characteristics of patients with Thalassemia Intermedia treated at the Pediatric Hematology Unit at the HaEmek Medical Center in Israel

Full description

The characteristics that will be recorded from the medical files include: demographic data, included gender and ethnic origin, family history, age at diagnosis, number and frequency of blood transfusions including age of first transfusion and physical examination findings.

The laboratory data included iron metabolism parameters, mutation in the alfa and beta gene and the presence of the xmn1 polymorphism.

Enrollment: 28 patients

Sex: All

Ages: 1 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-All patients treated at the Pediatric Hematology Unit

Exclusion criteria

• Not enough medical records.
• Patients who refuse to give consent to perform genetic studies will be included in the study but only the retrospective clinical data will be recorded.

Trial design

28 participants in 1 patient group

Thalassemia Intermedia Patients

Description:

Patients with Beta Thalassemia Intermedia treated at the Pediatric Hematology Unit. The characterization of Thalassemia Intermedia was based on age at diagnosis (Older than 2 ys) and / or clinical characteristics that are milder than Thalassemia Major in patients homozygous for beta globin genes.

Treatment:

Genetic: Laboratory analysis.