Dense Red Blood Cells in Sickle Cell Children (DREPADENSE)

Centre Hospitalier Intercommunal Creteil

Status: Terminated

Conditions: Sickle Cell Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02887118

DREPADENSE

Details and patient eligibility

About

Quantitative and prognostic evaluation of dense red blood cells in sickle cell children: preliminary single center study from the Creteil pediatric cohort.

Full description

An association between red blood cell density and hemolytic parameters, and clinical manifestations has been demonstrated in adults with sickle cell anemia.

This factor has not been studied in children. The identification of predictive biomarkers of disease severity, especially of specific pediatric complications (cerebral vasculopathy, splenic sequestration, Dactylitis) would be useful for optimal care of the children and early intensification Red blood cell density might be one of these prognostic factors.

Enrollment: 82 patients

Sex: All

Ages: 18 months to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 18 months-18 years
• Patient with sickle cell disease namely SS, or S / Beta0 or S / Beta +
• Patient regularly followed in the pediatric cohort of the CHI Creteil
• Patient Hospitalized for an annual check-up
• With or without intensification by Hydroxycarbamide
• patient who haven't been transfused within 3 months
• Whose parents have given their informed consent
• Patients insured to the French social scheme

Exclusion criteria

• Sickle cell SC disease
• Having received an allogeneic bone marrow transplantation
• Under regular transfusion program
• Having received a transfusion within 3 months

Trial design

82 participants in 1 patient group

Common arm

Description:

Children with sickle cell anemia will be included. Blood samples of all the included patients will be collected during a day-hospitalization for a planned chek-up. For all these patients the number of dense erythrocytes will be evaluated